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Ubiquinol supplementation positively correlates with reduced skeletal muscle damage in professional football players

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Ubiquinol supplementation positively correlates with reduced skeletal muscle damage in professional football players
© Athletic Club Bilbao

Ubiquinol is the reduced form of coenzyme Q10 (CoQ10), which is a lipid electron carrier that drives electrons from complex I, and complex II to complex III in the mitochondria respiratory chain, which is required for the synthesis of most of the ATP in cells. Deficiency of CoQ10 causes severe neuromuscular diseases particularly severe myopathies that courses with muscle damage that can reach rhabdomyolysis [1]. Professional football players have extreme physical activities during the season through the daily trainings but also by the regular games, which are really competitive and mainly when these players participate in different national and international leagues as it happens to Athletic Club Bilbao, Spanish First League Team.


I. Navas-Enamorado1,2, A. Sánchez-Cuesta1, P. Bjork2, J. del Rio2, T. Viar3, J. Lekue3, F. Angulo3, P. Navas1, G. López-Lluch1
1 Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC-JA, and CIBERER, Instituto de Salud Carlos III, Sevilla, Spain
2 100% Natural, Madrid, Spain
3 Athletic Club Bilbao, Bilbao, Spain


In order to study if a higher concentration of ubiquinol in blood would help the performance of players,we design a protocol to supply a blind selection of players with 300 mg ubiquinol/day (Kaneka Ubiquinol) and different extractions to study the evolution of blood content: 1) pre- season starting, final of the training pre-seasonal period, mid-season and final-season. Levels of ubiquinol in plasma after the pre-season was decreased relative to the basal content after vacations indicating that endurance exercise induced a decrease in blood as it was previously demonstrated in healthy young people [2].


The middle and final season extractions demonstrated that some of players were taken ubiquinol because these ones showed a significant increase independent of the exercise endurance preventing the decrease previously observed. The analysis of plasma demonstrated that cholesterol and triglycerides were unaffected during all the study and we observed a light increase of lipoperoxides as it was previously observed in a non-professional young players short-term study [3], but changes do not correlate with ubiquinol levels of players activities. We also analyzed creatine kinase (CK) as a marker of skeletal muscle damage and found that there was a negative correlation between the levels of both ubiquinol and CK in the player’s plasma of the third extraction indicating that ubiquinol would protect skeletal muscle cells from the extreme exercise caused by both daily training and weekly game.





[1] Desbats, M.A., et al., Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. J Inherit Metab Dis, 2015. 38(1): p. 145-56.
[2] Del Pozo-Cruz, J., et al., Physical activity affects plasma coenzyme Q10 levels differently in young and old humans. Biogerontology, 2014. 15(2): p. 199-211.
[3] Tauler, P., et al., Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer. Eur J Appl Physiol, 2008. 104(5): p. 777-85.

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